Qualification(s)

• Ph.D. in Biotechnology — Pondicherry Central University, Puducherry, India
  Thesis: Apoptotic and autophagic pathways mediated anticancer potential of novel selenolato-bridged manganese(I)-based carbon monoxide-releasing molecule and its molecular interactions with human serum albumin and DNA through experimental and computational approaches.
• Integrated B.Sc.-M.Sc. in Biotechnology — St. Xavier’s College (Autonomous), Kolkata, India

Specialization

• Molecular Biology
• Cell Biology
• Biotechnology
• Cancer Research

Research Areas

• Cancer Biology encompassing different programmed cell death pathways
• Anticancer drug development
• Protein/DNA binding via biophysical tools and techniques

Research Experience

Research Publications

8 peer-reviewed publications and one book chapter (Elsevier).

List of Publications

1. Tripathi, D., Sakthivel, N., Mohanty, A.K., Kumar, M.S., Kumar, U. and Manimaran, B., 2024. “Cytotoxic potential of novel selenolato-bridged manganese (I)-based CORM and its molecular interaction with human serum albumin and DNA through spectroscopic and in silico docking studies.” International Journal of Biological Macromolecules, 282, p.137191. DOI: 10.1016/j.ijbiomac.2024.137191 (IF: 8.7)
2. Tripathi, D., Mondal, M., Sakthivel. “Advanced materials for triggered release of drugs.” In: Medical Nanobiotechnology, January 2025, pp. 207–246. Ed. Sougata Ghosh and Thomas. Book chapter. ISBN: 978-0-443-21507-0. DOI: 10.1016/C2022-0-03164-0. Elsevier.
3. Anil, A., Tripathi, D., Shankar, S., Nayak, S.S., Krishna, R., Kumar, U., Manimaran, B. and Sakthivel, N., 2025. “Broad-spectrum anticancer properties, DFT calculations and macromolecular binding potential of a novel thiolato-bridged fac-Mn (CO)3-core-based CO-releasing molecule.” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , p.127406. DOI: 10.1016/j.saa.2025.127406 (IF: 4.8)
4. Shankar, S., Tripathi, D., Nayak, S.S., Krishna, R. and Sakthivel, N., 2026. “Prediction and Assessment of Anticancer, Antiproliferative, Pharmacokinetic Properties, and Human Serum Albumin Binding Propensity of a New Bioactive Marine Cyclic Dipeptide from Exiguobacterium profundum.” Marine Biotechnology, 28(1), p.3. DOI: 10.1007/s10126-025-10549-3 (IF: 2.9)
5. Anil, A., Tripathi, D., Nayak, S.S., Krishna, R., Kumar, U., Manimaran, B. and Sakthivel, N., 2026. “Elucidation of the molecular binding mechanism of an anticancer thiolato-bridged manganese (I) carbonyl complex with apotransferrin: Thermodynamic and structural insights.” Biochemical and Biophysical Research Communications , p.154135. DOI: 10.1016/j.bbrc.2026.154135 (IF: 2.2)
6. Anil, A., Tripathi, D., Nayak, S.S., Krishna, R., Kumar, U., Manimaran, B. and Sakthivel, N., 2026. “Simultaneous induction of apoptosis and ferroptosis by a novel thiolato-bridged manganese (I)-based CO-releasing molecule in pancreatic and prostate cancer cells.” Archives of Biochemistry and Biophysics, p.110942. DOI: 10.1016/j.abb.2026.110942 (IF: 3.5)
7. Nivas, S., Kumar, U., Das, D., Thamarainathan, D., Tripathi, D., Krishnaswamy, S., Padmanaban, R., Sakthivel, N. and Manimaran, B., 2025. “Heterofunctional spacer containing pyridyl ligands coordinated fac-Re (CO)3-core based dinuclear molecular rhomboids and their anticancer potential studies.” Journal of Molecular Structure, 1342, p.142741. DOI: 10.1016/j.molstruc.2025.142741 (IF: 4.7)
8. Magray, A.A., Varghese, J., Saravanan, N., Gupta, G., Lee, C.Y., Yeswanth Kumar, S., Padmanaban, R., Tripathi, D., Sakthivel, N. and Manimaran, B., 2025. “Rhenium (I)-Based Tetranuclear Metallorectangles from Linear BODIPY and Bischelating Aminoquinonato Ligands: Anticancer Properties, Host–Guest Interactions, and Molecular Docking Studies.” Inorganic Chemistry, 64(27), pp.13941–13955. DOI: 10.1021/acs.inorgchem.5c02079 (IF: 4.6)
9. Verma, S., Kumar, U., Thomas, G., Yeswanth Kumar, S., Tripathi, D., Padmanaban, R., Sakthivel, N. and Manimaran, B., 2025. “Multicomponent Self-Assembly of Manganese (I)-Based NN∩NN Bis-Chelated Dinuclear Metallacrown Ethers: Synthesis, Characterization, Cation Binding, and Cytotoxicity Studies.” ACS Omega, 10(45), pp.53760–53774. DOI: 10.1021/acsomega.4c10992 (IF: 5.1)

Fellowships & Awards

• CSIR-JRF and CSIR-SRF fellow with AIR 38

Conferences, Workshops & Presentations

• Oral Presentation: Diksha Tripathi and Natarajan Sakthivel, “Investigation of cytotoxic potential of novel Mn-CORM in ovarian cancer and elucidation of its molecular interaction with human serum albumin.” International Conference on Recent Innovations in Biotechnology, Sathyabama Institute of Science and Technology, Chennai, 21–23 September 2023. Oral Presentation, Conference Proceedings I-CRIB (2023): AB 008.
• Participated in the National Conference on “Recent Advances in Biodiversity, Biology and Biotechnology of Fungi” , organized by the Department of Biotechnology, Pondicherry University, 7–9 November 2019.
• Participated in the National Workshop on Macromolecular Crystallography, organized by the Centre for Bioinformatics, Pondicherry University, 18 December 2019.
• Participated in the 45th Annual Meeting of Plant Tissue Culture Association & National Symposium on “Recent Advances in Plant Biotechnology”, organized by the Department of Biotechnology, Pondicherry University, 23–25 January 2024.